četrtek, 09. junij 2011

Nicotine - nikotin

Nicotine, alkaloid obtained from the tobacco plant Nicotiana tabacum is TOXIC to many animals, because it mimicks the action of the neurotransmitter acetylcholine (ACH) at NEURO-MUSCULAR junctions (motorične ploščice na stiku živca in skeletnih mišic). (//Eckert animal physiology)

Ni čudn, da si mal počasen, če kadiš.
Še sreča, da se nanaša na živali, kar pa ljudje itak nismo, anede.

Lol, tole pa piše na wikipediji, pod njegovo toksičnost.
The LD50 of nicotine is 50 mg/kg for rats and 3 mg/kg for mice. 40–60 mg (0.5-1.0 mg/kg) can be a lethal dosage for adult humans.[55][56] Nicotine therefore has a high toxicity in comparison to many other alkaloids such as cocaine, which has an LD50 of 95.1 mg/kg when administered to mice.

No, pa da bom fer: "It is unlikely that a person would overdose on nicotine through smoking alone, although overdose can occur through combined use of nicotine patches or nicotine gum and cigarettes at the same time.[57] Spilling a high concentration of nicotine onto the skin can cause intoxication or even death, since nicotine readily passes into the bloodstream following dermal contact."
in še:
Though the teratogenic properties of nicotine may or may not yet have been adequately researched, women who use nicotine gum and patches during the early stages of pregnancy face an increased risk of having babies with birth defects, according to a study of around 77,000 pregnant women in Denmark.
    The study found that women who use nicotine-replacement therapy in the first 12 weeks of pregnancy have a 60 percent greater risk of having babies with birth defects, compared to women who are non-smokers, the Daily Mail reported. The findings were published in the journal Obstetrics and Gynaecology.

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